Advances in Acute Severe Hepatitis of Unknown Etiology in Children

Since the International Health Regulations National Focal Point for United Kingdom alerted WHO of ten cases acute severe hepatitis unknown etiology in children on April 5, 2022, relevant have been reported worldwide. These patients had (negative viruses A–E) and elevated aminotransferase (AST) or alanine aminase (ALT) exceeding 500 U/L. Furthermore, respiratory syndrome coronavirus type 2 (SARS-CoV-2) and/or adenovirus F41 detected some cases. This has hypothesized to be induced by a viral reservoir novel superantigen, which repeatedly stimulates intestines leads multisystem inflammatory (MIS-C), causes immune abnormalities presence human adenovirus. Although this hypothesis not confirmed any vivo experimental clinical studies, it may provide ideas possible intervention strategies.